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10.1016/j.mehy.2016.02.018 http://scihub22266oqcxt.onion/10.1016/j.mehy.2016.02.018 C4829918!4829918 !27063077     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27063077 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27063077 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Med+Hypotheses 2016 ; 90 (ä): 11-3 Nephropedia Template TP {{tp|p=27063077 |t=2016. Melanoma exosomes enable tumor tolerance in lymph nodes |pdf=|usr=}}{{27063077 }} gab.com Text Melanoma exosomes enable tumor tolerance in lymph nodes JO: Med Hypotheses http://www.kidney.de/pget.php?&tw=1&pmid=27063077 #FOAvip Melanoma preferentially spreads via lymph nodes. Melanoma exosomes can induce angiogenesis and immune suppression. However, a role for melanoma exosomes in facilitating tumor tolerance in lymph nodes has not been considered. Herein, the hypothesis that melanoma exosome mediated induction of vascular endothelial cell (VEC) derived tumor necrosis factor alpha (TNF-?) results in lymphatic endothelial cell (LEC) mediated tumor tolerance is explored. To support this hypothesis, experiments involving ex vivo lymph node associated VECs, LECs, dendritic cells and T lymphocytes are proposed based upon a previously established fluorescent exosome lymph node trafficking model. The implication of the hypothesis in the context of melanoma exosome mediated induction of tumor tolerance in lymph nodes is then discussed. Twit Text FOAVip Melanoma exosomes enable tumor tolerance in lymph nodes ????Med Hypotheses http://www.kidney.de/pget.php?&tw=1&pmid=27063077 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27063077 #FOAvip English Wikipedia <ref>{{Cite pmid|27063077 }}</ref> Melanoma exosomes enable tumor tolerance in lymph nodes #MMPMID27063077 Hood JL Med Hypotheses 2016[May]; 90 (ä): 11-3 PMID27063077 show ga Melanoma preferentially spreads via lymph nodes. Melanoma exosomes can induce angiogenesis and immune suppression. However, a role for melanoma exosomes in facilitating tumor tolerance in lymph nodes has not been considered. Herein, the hypothesis that melanoma exosome mediated induction of vascular endothelial cell (VEC) derived tumor necrosis factor alpha (TNF-?) results in lymphatic endothelial cell (LEC) mediated tumor tolerance is explored. To support this hypothesis, experiments involving ex vivo lymph node associated VECs, LECs, dendritic cells and T lymphocytes are proposed based upon a previously established fluorescent exosome lymph node trafficking model. The implication of the hypothesis in the context of melanoma exosome mediated induction of tumor tolerance in lymph nodes is then discussed. |*Models, Immunological [MESH] |Antigens, Neoplasm/immunology [MESH] |Dendritic Cells/immunology [MESH] |Endothelial Cells/metabolism/physiology [MESH] |Exosomes/*physiology [MESH] |Humans [MESH] |Lymph Nodes/*immunology [MESH] |Lymphatic Metastasis/*immunology [MESH] |Melanoma, Experimental/immunology/pathology [MESH] |Melanoma/*immunology/pathology [MESH] |Research Design [MESH] |T-Lymphocyte Subsets/immunology [MESH] |Tumor Escape/*immunology [MESH]Melanoma exosomes enable tumor tolerance in lymph nodes (epmc).pdf DeepDyve Pubget Overpricing