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2015 ; 31
(2
): 297-9
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Megaloblastic anemia presenting with massive reversible splenomegaly
#MMPMID25825577
Behera V
; Randive M
; Sharma P
; Nair V
Indian J Hematol Blood Transfus
2015[Jun]; 31
(2
): 297-9
PMID25825577
show ga
Megaloblastic anemia (MA) is a common disorder with varied manifestations. It
generally results in mild to moderate splenomegaly which is due to sequestration
of macrocytic erythrocytes in spleen. Massive splenomegaly is generally seen in
infections, myeloproliferative diseases, neoplasms, storage disorders or
hematological conditions; but is not heard of and has rarely been reported in MA.
We discuss a case of massive splenomegaly who presented with symptomatic anemia
and was found to have MA. He was extensive evaluated for all other causes of
massive splenomegaly which was normal. Further, after a therapeutic trial of MA
he showed a regression in spleen size confirming that the massive splenomegaly
was attributable to MA.