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2016 ; 12
(3
): 659-66
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Medulloblastoma: molecular pathways and histopathological classification
#MMPMID27279861
Borowska A
; Jó?wiak J
Arch Med Sci
2016[Jun]; 12
(3
): 659-66
PMID27279861
show ga
Malignant brain tumors are the leading cause of cancer death among pediatric
patients, and medulloblastoma constitutes 20% of them. Currently, the treatment
is risk-adapted. Maximum surgical resection is recommended, always followed by
chemotherapy and neuroaxis radiotherapy. In spite of the improving survival rate,
survivors succumb to treatment-induced side effects. To reduce toxic effects,
molecular-targeted treatment is proposed. Medulloblastoma research is very
robust, and new articles on the subject are published daily. In the current
review we have tried to bring together molecular pathophysiology of the neoplasm
and current pathological classification, thus making an effort to relate tumor
biology and the histological picture.