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2017 ; 17
(2
): 162-174
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Medication-Induced Tardive Dyskinesia: A Review and Update
#MMPMID28638290
Cornett EM
; Novitch M
; Kaye AD
; Kata V
; Kaye AM
Ochsner J
2017[Sum]; 17
(2
): 162-174
PMID28638290
show ga
BACKGROUND: Tardive dyskinesia (TD) is a movement disorder that causes
involuntary, repetitive body movements and is commonly seen in patients who are
on long-term treatment with antipsychotic medications. However, several other
classes of medications with different mechanisms are also associated with TD.
METHODS: We conducted a PubMed search using keywords and combined word searches
that involved medication-induced TD, as well as agents that are associated with
causing or are used to treat medication-induced TD. We attempted to include as
many recent (publication date of 2015 and later) articles as possible. RESULTS:
The reported incidence of TD seems to be reduced with the use of atypical
antipsychotic drugs, yet the risk of developing TD remains with these
medications. Furthermore, several other medication classes have a high prevalence
of TD and yet are not commonly considered to be TD-inducing. This review
highlights the need for a prevention-based focus of TD treatment that starts with
a clinical consideration of pharmacologic choices related to each individual
patient's history. CONCLUSION: This review offers the information current as of
2016 on the pathophysiology, etiology, and epidemiology of TD, as well as the
medications associated with TD, mechanisms of medication-induced TD, and
treatments for medication-induced TD.