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2015 ; 38
(3
): 74-8
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Medical management of malignant melanoma
#MMPMID26648623
Atkinson V
Aust Prescr
2015[Jun]; 38
(3
): 74-8
PMID26648623
show ga
The treatment and outcomes for people with metastatic melanoma have changed
considerably in the past few years with the introduction of targeted anticancer
drugs. About half of the patients with metastatic melanoma will have activating
mutations in the BRAF gene. These people may benefit from a BRAF inhibitor
(vemurafenib or dabrafenib) or a MEK inhibitor (trametinib). Addition of a MEK
inhibitor to a BRAF inhibitor improves progression-free survival and alters the
adverse effect profile. Ipilimumab is another drug indicated for metastatic
melanoma. It works by altering the patient's own immune response to the tumour.
Toxicities are common with these drugs and include arthralgias, fatigue,
photosensitivity, squamous cell carcinomas, fever, diarrhoea, pruritus and
immune-related adverse effects.