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2014 ; 35
(23
): 1515-25
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Medial vascular calcification revisited: review and perspectives
#MMPMID24740885
Lanzer P
; Boehm M
; Sorribas V
; Thiriet M
; Janzen J
; Zeller T
; St Hilaire C
; Shanahan C
Eur Heart J
2014[Jun]; 35
(23
): 1515-25
PMID24740885
show ga
Vascular calcifications (VCs) are actively regulated biological processes
associated with crystallization of hydroxyapatite in the extracellular matrix and
in cells of the media (VCm) or intima (VCi) of the arterial wall. Both patterns
of VC often coincide and occur in patients with type II diabetes, chronic kidney
disease, and other less frequent disorders; VCs are also typical in senile
degeneration. In this article, we review the current state of knowledge about the
pathology, molecular biology, and nosology of VCm, expand on potential mechanisms
responsible for poor prognosis, and expose some of the directions for future
research in this area.
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