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2017 ; 112
(9
): 1962-1974
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Mechanotransduction Dynamics at the Cell-Matrix Interface
#MMPMID28494966
Weinberg SH
; Mair DB
; Lemmon CA
Biophys J
2017[May]; 112
(9
): 1962-1974
PMID28494966
show ga
The ability of cells to sense and respond to mechanical cues from the surrounding
environment has been implicated as a key regulator of cell differentiation,
migration, and proliferation. The extracellular matrix (ECM) is an oft-overlooked
component of the interface between cells and their surroundings. Cells assemble
soluble ECM proteins into insoluble fibrils with unique mechanical properties
that can alter the mechanical cues a cell receives. In this study, we construct a
model that predicts the dynamics of cellular traction force generation and
subsequent assembly of fibrils of the ECM protein fibronectin (FN). FN fibrils
are the primary component in primordial ECM and, as such, FN assembly is a
critical component in the cellular mechanical response. The model consists of a
network of Hookean springs, each representing an extensible domain within an
assembling FN fibril. As actomyosin forces stretch the spring network,
simulations predict the resulting traction force and FN fibril formation. The
model accurately predicts FN fibril morphometry and demonstrates a mechanism by
which FN fibril assembly regulates traction force dynamics in response to
mechanical stimuli and varying surrounding substrate stiffness.
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