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10.1038/embor.2013.49 http://scihub22266oqcxt.onion/10.1038/embor.2013.49 C3674437!3674437 !23681438     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23681438 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       EMBO+Rep 2013 ; 14 (6 ): 509-19 Nephropedia Template TP {{tp|p=23681438 |t=2013. Mechanosensitivity and compositional dynamics of cell-matrix adhesions |pdf=|usr=}}{{23681438 }} gab.com Text Mechanosensitivity and compositional dynamics of cell-matrix adhesions JO: EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=23681438 #FOAvip Cells perceive information about the biochemical and biophysical properties of their tissue microenvironment through integrin-mediated cell-matrix adhesions, which connect the cytoskeleton with the extracellular matrix and thereby allow cohesion and long-range mechanical connections within tissues. The formation of cell-matrix adhesions and integrin signalling involves the dynamic recruitment and assembly of an inventory of proteins, collectively termed the 'adhesome', at the adhesive site. The recruitment of some adhesome proteins, most notably the Lin11-, Isl1- and Mec3-domain-containing proteins, depends on mechanical tension generated by myosin II-mediated contractile forces exerted on cell-matrix adhesions. When exposed to force, mechanosensitive adhesome proteins can change their conformation or expose cryptic-binding sites leading to the recruitment of proteins, rearrangement of the cytoskeleton, reinforcement of the adhesive site and signal transduction. Biophysical methods and proteomics revealed force ranges within the adhesome and cytoskeleton, and also force-dependent changes in adhesome composition. In this review, we provide an overview of the compositional dynamics of cell-matrix adhesions, discuss the most prevalent functional domains in adhesome proteins and review literature and concepts about mechanosensing mechanisms that operate at the adhesion site. Twit Text FOAVip Mechanosensitivity and compositional dynamics of cell-matrix adhesions ????EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=23681438 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23681438 #FOAvip English Wikipedia <ref>{{Cite pmid|23681438 }}</ref> Mechanosensitivity and compositional dynamics of cell-matrix adhesions #MMPMID23681438 Schiller HB ; Fässler R EMBO Rep 2013[Jun]; 14 (6 ): 509-19 PMID23681438 show ga Cells perceive information about the biochemical and biophysical properties of their tissue microenvironment through integrin-mediated cell-matrix adhesions, which connect the cytoskeleton with the extracellular matrix and thereby allow cohesion and long-range mechanical connections within tissues. The formation of cell-matrix adhesions and integrin signalling involves the dynamic recruitment and assembly of an inventory of proteins, collectively termed the 'adhesome', at the adhesive site. The recruitment of some adhesome proteins, most notably the Lin11-, Isl1- and Mec3-domain-containing proteins, depends on mechanical tension generated by myosin II-mediated contractile forces exerted on cell-matrix adhesions. When exposed to force, mechanosensitive adhesome proteins can change their conformation or expose cryptic-binding sites leading to the recruitment of proteins, rearrangement of the cytoskeleton, reinforcement of the adhesive site and signal transduction. Biophysical methods and proteomics revealed force ranges within the adhesome and cytoskeleton, and also force-dependent changes in adhesome composition. In this review, we provide an overview of the compositional dynamics of cell-matrix adhesions, discuss the most prevalent functional domains in adhesome proteins and review literature and concepts about mechanosensing mechanisms that operate at the adhesion site. |*Cell Adhesion [MESH] |*Mechanotransduction, Cellular [MESH] |Animals [MESH] |Cell Adhesion Molecules/chemistry/metabolism [MESH] |Extracellular Matrix/*physiology [MESH] |Feedback, Physiological [MESH] |Focal Adhesions/physiology [MESH] |Humans [MESH] |Integrins/metabolism [MESH] |Myosin Type II/metabolism [MESH]Mechanosensitivity and compositional dynamics of cell-matrix adhesions(epmc).pdf DeepDyve Pubget Overpricing