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2016 ; 49
(8
): 403-4
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Mechanosensitive ?-catenin signaling regulates lymphatic vascular development
#MMPMID27418286
Cha B
; Srinivasan RS
BMB Rep
2016[Aug]; 49
(8
): 403-4
PMID27418286
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The Wnt/?-catenin signaling is an evolutionarily conserved pathway that plays a
pivotal role in embryonic development and adult homeostasis. However, we have
limited information about the involvement of Wnt/?-catenin signaling in the
lymphatic vascular system that regulates fluid homeostasis by absorbing
interstitial fluid and returning it to blood circulation. In this recent
publication we report that canonical Wnt/?-catenin signaling is highly active and
critical for the formation of lymphovenus valves (LVVs) and lymphatic valves
(LVs). ?-catenin directly associates with the regulatory elements of the
lymphedema-associated transcription factor, FOXC2 and activates its expression in
an oscillatory shear stress (OSS)-dependent manner. The phenotype of ?-catenin
null embryos was rescued by FOXC2 overexpression. These results suggest that
Wnt/?-catenin signaling is a mechanotransducer that links fluid force with
lymphatic vascular development. [BMB Reports 2016; 49(8): 403-404].
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