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10.1126/science.aah6130 http://scihub22266oqcxt.onion/10.1126/science.aah6130 C5380214!5380214 !28104892     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28104892 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28104892 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Science 2017 ; 355 (6322 ): 298-302 Nephropedia Template TP {{tp|p=28104892 |t=2017. Mechanistic basis for a molecular triage reaction |pdf=|usr=}}{{28104892 }} gab.com Text Mechanistic basis for a molecular triage reaction JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=28104892 #FOAvip Newly synthesized proteins are triaged between biosynthesis and degradation to maintain cellular homeostasis, but the decision-making mechanisms are unclear. We reconstituted the core reactions for membrane targeting and ubiquitination of nascent tail-anchored membrane proteins to understand how their fate is determined. The central six-component triage system is divided into an uncommitted client-SGTA complex, a self-sufficient targeting module, and an embedded but self-sufficient quality control module. Client-SGTA engagement of the targeting module induces rapid, private, and committed client transfer to TRC40 for successful biosynthesis. Commitment to ubiquitination is dictated primarily by comparatively slower client dissociation from SGTA and nonprivate capture by the BAG6 subunit of the quality control module. Our results provide a paradigm for how priority and time are encoded within a multichaperone triage system. Twit Text FOAVip Mechanistic basis for a molecular triage reaction ????Science http://www.kidney.de/pget.php?&tw=1&pmid=28104892 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28104892 #FOAvip English Wikipedia <ref>{{Cite pmid|28104892 }}</ref> Mechanistic basis for a molecular triage reaction #MMPMID28104892 Shao S ; Rodrigo-Brenni MC ; Kivlen MH ; Hegde RS Science 2017[Jan]; 355 (6322 ): 298-302 PMID28104892 show ga Newly synthesized proteins are triaged between biosynthesis and degradation to maintain cellular homeostasis, but the decision-making mechanisms are unclear. We reconstituted the core reactions for membrane targeting and ubiquitination of nascent tail-anchored membrane proteins to understand how their fate is determined. The central six-component triage system is divided into an uncommitted client-SGTA complex, a self-sufficient targeting module, and an embedded but self-sufficient quality control module. Client-SGTA engagement of the targeting module induces rapid, private, and committed client transfer to TRC40 for successful biosynthesis. Commitment to ubiquitination is dictated primarily by comparatively slower client dissociation from SGTA and nonprivate capture by the BAG6 subunit of the quality control module. Our results provide a paradigm for how priority and time are encoded within a multichaperone triage system. |*Models, Molecular [MESH] |*Protein Biosynthesis [MESH] |*Proteolysis [MESH] |Arsenite Transporting ATPases/chemistry [MESH] |Carrier Proteins/chemistry [MESH] |Membrane Proteins/*chemistry [MESH] |Molecular Chaperones/chemistry [MESH]Mechanistic basis for a molecular triage reaction (epmc).pdf DeepDyve Pubget Overpricing