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10.1038/nrg3729 http://scihub22266oqcxt.onion/10.1038/nrg3729 C6044419!6044419 !24981601     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24981601 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24981601 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Rev+Genet 2014 ; 15 (9 ): 585-98 Nephropedia Template TP {{tp|p=24981601 |t=2014. Mechanisms underlying mutational signatures in human cancers |pdf=|usr=}}{{24981601 }} gab.com Text Mechanisms underlying mutational signatures in human cancers JO: Nat Rev Genet http://www.kidney.de/pget.php?&tw=1&pmid=24981601 #FOAvip The collective somatic mutations observed in a cancer are the outcome of multiple mutagenic processes that have been operative over the lifetime of a patient. Each process leaves a characteristic imprint--a mutational signature--on the cancer genome, which is defined by the type of DNA damage and DNA repair processes that result in base substitutions, insertions and deletions or structural variations. With the advent of whole-genome sequencing, researchers are identifying an increasing array of these signatures. Mutational signatures can be used as a physiological readout of the biological history of a cancer and also have potential use for discerning ongoing mutational processes from historical ones, thus possibly revealing new targets for anticancer therapies. Twit Text FOAVip Mechanisms underlying mutational signatures in human cancers ????Nat Rev Genet http://www.kidney.de/pget.php?&tw=1&pmid=24981601 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24981601 #FOAvip English Wikipedia <ref>{{Cite pmid|24981601 }}</ref> Mechanisms underlying mutational signatures in human cancers #MMPMID24981601 Helleday T ; Eshtad S ; Nik-Zainal S Nat Rev Genet 2014[Sep]; 15 (9 ): 585-98 PMID24981601 show ga The collective somatic mutations observed in a cancer are the outcome of multiple mutagenic processes that have been operative over the lifetime of a patient. Each process leaves a characteristic imprint--a mutational signature--on the cancer genome, which is defined by the type of DNA damage and DNA repair processes that result in base substitutions, insertions and deletions or structural variations. With the advent of whole-genome sequencing, researchers are identifying an increasing array of these signatures. Mutational signatures can be used as a physiological readout of the biological history of a cancer and also have potential use for discerning ongoing mutational processes from historical ones, thus possibly revealing new targets for anticancer therapies. |*DNA Damage [MESH] |*DNA Repair [MESH] |DNA Mutational Analysis [MESH] |DNA, Neoplasm/*genetics [MESH] |Genome, Human/*genetics [MESH] |Humans [MESH] |Mutation [MESH] |Neoplasms/*genetics [MESH]Mechanisms underlying mutational signatures in human cancers (epmc).pdf DeepDyve Pubget Overpricing