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10.1097/WCO.0000000000000184 http://scihub22266oqcxt.onion/10.1097/WCO.0000000000000184 C5034868!5034868 !25734955     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25734955 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25734955 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Curr+Opin+Neurol 2015 ; 28 (2 ): 166-74 Nephropedia Template TP {{tp|p=25734955 |t=2015. Mechanisms of sudden unexplained death in epilepsy |pdf=|usr=}}{{25734955 }} gab.com Text Mechanisms of sudden unexplained death in epilepsy JO: Curr Opin Neurol http://www.kidney.de/pget.php?&tw=1&pmid=25734955 #FOAvip PURPOSE OF REVIEW: Human and experimental research has identified cardioautonomic and respiratory dysfunction as a frequent accompaniment in human and animal model events of sudden unexpected death in epilepsy (SUDEP). This review aims to provide an overview of the scientific evidence behind the currently accepted risk factors and working hypotheses regarding SUDEP pathophysiology. RECENT FINDINGS: Epidemiological analysis of public health burden of SUDEP has shown that it rates second only to stroke in the years of potential life lost. Clinical and experimental studies uncovered the dynamic cardiorespiratory dysfunction interictally and imminently to SUDEP, and model systems have facilitated discoveries in SUDEP mechanistic understanding and application of pilot therapeutic interventions. Pilot molecular profiling of human SUDEP has uncovered complex genomic structure in the candidate gene network. SUMMARY: Extensive clinical and experimental work has established a rationale for the conceptual thinking about SUDEP mechanisms. The application of the global molecular profiling will be invaluable in unraveling the individually unique genomic complexities and interactions that underlie the physiological signature of each patient. At the same time, sophisticated model systems will be critical in the iterative translation of human genetics, physiology, pharmacological interventions, and in testing preventive interventions. Twit Text FOAVip Mechanisms of sudden unexplained death in epilepsy ????Curr Opin Neurol http://www.kidney.de/pget.php?&tw=1&pmid=25734955 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25734955 #FOAvip English Wikipedia <ref>{{Cite pmid|25734955 }}</ref> Mechanisms of sudden unexplained death in epilepsy #MMPMID25734955 Goldman AM Curr Opin Neurol 2015[Apr]; 28 (2 ): 166-74 PMID25734955 show ga PURPOSE OF REVIEW: Human and experimental research has identified cardioautonomic and respiratory dysfunction as a frequent accompaniment in human and animal model events of sudden unexpected death in epilepsy (SUDEP). This review aims to provide an overview of the scientific evidence behind the currently accepted risk factors and working hypotheses regarding SUDEP pathophysiology. RECENT FINDINGS: Epidemiological analysis of public health burden of SUDEP has shown that it rates second only to stroke in the years of potential life lost. Clinical and experimental studies uncovered the dynamic cardiorespiratory dysfunction interictally and imminently to SUDEP, and model systems have facilitated discoveries in SUDEP mechanistic understanding and application of pilot therapeutic interventions. Pilot molecular profiling of human SUDEP has uncovered complex genomic structure in the candidate gene network. SUMMARY: Extensive clinical and experimental work has established a rationale for the conceptual thinking about SUDEP mechanisms. The application of the global molecular profiling will be invaluable in unraveling the individually unique genomic complexities and interactions that underlie the physiological signature of each patient. At the same time, sophisticated model systems will be critical in the iterative translation of human genetics, physiology, pharmacological interventions, and in testing preventive interventions. |*Genetic Predisposition to Disease [MESH] |Animals [MESH] |Death, Sudden/*etiology/prevention & control [MESH] |Disease Models, Animal [MESH] |Epilepsy/*genetics/*mortality/physiopathology [MESH] |Humans [MESH] |Risk Factors [MESH]Mechanisms of sudden unexplained death in epilepsy (epmc).pdf DeepDyve Pubget Overpricing