Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25701233
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Biochim+Biophys+Acta
2015 ; 1848
(11 Pt B
): 3055-61
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Mechanisms of resistance to antimicrobial peptides in staphylococci
#MMPMID25701233
Joo HS
; Otto M
Biochim Biophys Acta
2015[Nov]; 1848
(11 Pt B
): 3055-61
PMID25701233
show ga
Staphylococci are commensal bacteria living on the epithelial surfaces of humans
and other mammals. Many staphylococci, including the dangerous pathogen
Staphylococcus aureus, can cause severe disease when they breach the epithelial
barrier. Both during their commensal life and during infection, staphylococci
need to evade mechanisms of innate host defense, of which antimicrobial peptides
(AMPs) play a key role in particular on the skin. Mechanisms that staphylococci
have developed to evade the bactericidal activity of AMPs are manifold,
comprising repulsion of AMPs via alteration of cell wall and membrane surface
charges, proteolytic inactivation, sequestration, and secretion. Furthermore,
many staphylococci form biofilms, which represents an additional way of
protection from antimicrobial agents, including AMPs. Finally, staphylococci can
sense the presence of AMPs by sensor/regulator systems that control many of those
resistance mechanisms. This article is part of a Special Issue entitled:
Bacterial Resistance to Antimicrobial Peptides.
|*Drug Resistance, Bacterial
[MESH]
|Animals
[MESH]
|Anti-Bacterial Agents/therapeutic use
[MESH]
|Antimicrobial Cationic Peptides/immunology/*metabolism/therapeutic use
[MESH]
|Bacterial Proteins/metabolism
[MESH]
|Biofilms/growth & development
[MESH]
|Host-Pathogen Interactions
[MESH]
|Humans
[MESH]
|Immune Evasion
[MESH]
|Immunity, Innate
[MESH]
|Membrane Transport Proteins/metabolism
[MESH]
|Microbial Viability
[MESH]
|Signal Transduction
[MESH]
|Staphylococcal Infections/immunology/*metabolism/microbiology/prevention &
control
[MESH]