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Mechanisms of myoblast fusion during muscle development
#MMPMID25989064
Kim JH
; Jin P
; Duan R
; Chen EH
Curr Opin Genet Dev
2015[Jun]; 32
(?): 162-70
PMID25989064
show ga
The development and regeneration of skeletal muscle require the fusion of
mononucleated muscle cells to form multinucleated, contractile muscle fibers.
Studies using a simple genetic model, Drosophila melanogaster, have discovered
many evolutionarily conserved fusion-promoting factors in vivo. Recent work in
zebrafish and mouse also identified several vertebrate-specific factors required
for myoblast fusion. Here, we integrate progress in multiple in vivo systems and
highlight conceptual advance in understanding how muscle cell membranes are
brought together for fusion. We focus on the molecular machinery at the fusogenic
synapse and present a three-step model to describe the molecular and cellular
events leading to fusion pore formation.
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