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2013 ; 5
(6
): ä Nephropedia Template TP
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Mechanisms of mitochondrial fission and fusion
#MMPMID23732471
van der Bliek AM
; Shen Q
; Kawajiri S
Cold Spring Harb Perspect Biol
2013[Jun]; 5
(6
): ä PMID23732471
show ga
Mitochondria continually change shape through the combined actions of fission,
fusion, and movement along cytoskeletal tracks. The lengths of mitochondria and
the degree to which they form closed networks are determined by the balance
between fission and fusion rates. These rates are influenced by metabolic and
pathogenic conditions inside mitochondria and by their cellular environment.
Fission and fusion are important for growth, for mitochondrial redistribution,
and for maintenance of a healthy mitochondrial network. In addition,
mitochondrial fission and fusion play prominent roles in disease-related
processes such as apoptosis and mitophagy. Three members of the Dynamin family
are key components of the fission and fusion machineries. Their functions are
controlled by different sets of adaptor proteins on the surface of mitochondria
and by a range of regulatory processes. Here, we review what is known about these
proteins and the processes that regulate their actions.