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Mechanisms of immune evasion in breast cancer
#MMPMID29751789
Bates JP
; Derakhshandeh R
; Jones L
; Webb TJ
BMC Cancer
2018[May]; 18
(1
): 556
PMID29751789
show ga
Tumors develop multiple mechanisms of immune evasion as they progress, with some
cancer types being inherently better at 'hiding' than others. With an increased
understanding of tumor immune surveillance, immunotherapy has emerged as a
promising treatment strategy for breast cancer, despite historically being
thought of as an immunologically silent neoplasm. Some types of cancer, such as
melanoma, bladder, and renal cell carcinoma, have demonstrated a durable response
to immunotherapeutic intervention, however, breast neoplasms have not shown the
same efficacy. The causes of breast cancer's immune silence derive from
mechanisms that diminish immune recognition and others that promote strong
immunosuppression. It is the mechanisms of immune evasion in breast cancers that
are poorly defined. Thus, further characterization is critical for the
development of better therapies. This brief review will seek to provide insight
into the possible causes of weak immunogenicity and immune suppression mediated
by breast cancers and highlight current immunotherapies being used to restore
immune responses to breast cancer.
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