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2014 ; 30
(6
): 230-6
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Mechanisms of epigenetic memory
#MMPMID24780085
D'Urso A
; Brickner JH
Trends Genet
2014[Jun]; 30
(6
): 230-6
PMID24780085
show ga
Although genetics has an essential role in defining the development, morphology,
and physiology of an organism, epigenetic mechanisms have an essential role in
modulating these properties by regulating gene expression. During development,
epigenetic mechanisms establish stable gene expression patterns to ensure proper
differentiation. Such mechanisms also allow organisms to adapt to environmental
changes and previous experiences can impact the future responsiveness of an
organism to a stimulus over long timescales and even over generations. Here, we
discuss the concept of epigenetic memory, defined as the stable propagation of a
change in gene expression or potential induced by developmental or environmental
stimuli. We highlight three distinct paradigms of epigenetic memory that operate
on different timescales.