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10.3978/j.issn.2223-3652.2015.06.05

http://scihub22266oqcxt.onion/10.3978/j.issn.2223-3652.2015.06.05
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suck abstract from ncbi


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pmid26543821
      Cardiovasc+Diagn+Ther 2015 ; 5 (5 ): 343-52
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  • Mechanisms of ectopic calcification: implications for diabetic vasculopathy #MMPMID26543821
  • Avogaro A ; Fadini GP
  • Cardiovasc Diagn Ther 2015[Oct]; 5 (5 ): 343-52 PMID26543821 show ga
  • Vascular calcification (VC) is the deposition of calcium/phosphate in the vasculature, which portends a worse clinical outcome and predicts major adverse cardiovascular events. VC is an active process initiated and regulated via a variety of molecular signalling pathways. There are mainly two types of calcifications: the media VC and the intima VC. All major risk factors for cardiovascular disease (CVD) have been linked to the presence/development of VC. Besides the risk factors, a genetic component is also operative to determine arterial calcification. Several events take place before VC is established, including inflammation, trans-differentiation of vascular cells and homing of circulating pro-calcific cells. Diabetes is an important predisposing factor for VC. Compared with non-diabetic subjects, patients with diabetes show increased VC and higher expression of bone-related proteins in the medial layer of the vessels. In this review we will highlight the mechanisms underlying vascular calcification in diabetic patients.
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