Mechanisms of Immune Tolerance in Leukemia and Lymphoma
#MMPMID28511816
Curran EK
; Godfrey J
; Kline J
Trends Immunol
2017[Jul]; 38
(7
): 513-525
PMID28511816
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The mechanisms through which immune responses are generated against solid cancers
are well characterized and knowledge of the immune evasion pathways exploited by
these malignancies has grown considerably. However, for hematological cancers,
which develop and disseminate quite differently than solid tumors, the pathways
that regulate immune activation or tolerance are less clear. Growing evidence
suggests that, while numerous immune escape pathways are shared between
hematological and solid malignancies, several unique pathways are exploited by
leukemia and lymphoma. Below we discuss immune evasion mechanisms in leukemia and
lymphoma, highlighting key differences from solid tumors. A more complete
characterization of the mechanisms of immune tolerance in hematological
malignancies is critical to inform the development of future immunotherapeutic
approaches.
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