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2017 ; 11
(ä): 272
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Mechanisms of Hierarchical Cortical Maturation
#MMPMID28959187
Chomiak T
; Hu B
Front Cell Neurosci
2017[]; 11
(ä): 272
PMID28959187
show ga
Cortical information processing is structurally and functionally organized into
hierarchical pathways, with primary sensory cortical regions providing modality
specific information and associative cortical regions playing a more integrative
role. Historically, there has been debate as to whether primary cortical regions
mature earlier than associative cortical regions, or whether both primary and
associative cortical regions mature simultaneously. Identifying whether primary
and associative cortical regions mature hierarchically or simultaneously will not
only deepen our understanding of the mechanisms that regulate brain maturation,
but it will also provide fundamental insight into aspects of adolescent behavior,
learning, neurodevelopmental disorders and computational models of neural
processing. This mini-review article summarizes the current evidence supporting
the sequential and hierarchical nature of cortical maturation, and then proposes
a new cellular model underlying this process. Finally, unresolved issues
associated with hierarchical cortical maturation are also addressed.