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Mechanisms linking obesity to male infertility
#MMPMID25914843
Katib A
Cent European J Urol
2015[]; 68
(1
): 79-85
PMID25914843
show ga
INTRODUCTION: Obesity in men is associated with infertility in numerous studies.
The current trend for decline in semen parameters parallels the increasing
prevalence of obesity worldwide. In addition to impaired semen quality, fertility
among obese men may be affected by sexual dysfunction, endocrinopathy,
aromatization activity, psychological and thermal effects, sleep apnea, leptin
and minor toxins, and possibly the inflammatory and obstructive elements of
epididymitis pathology. The variable degrees of certainty associated with these
causes parallel the levels of supporting evidence. This search aims to shed
lights on different conditions that obese men suffer from; as that makes the
treatment of infertility more categorized. MATERIAL AND METHODS: A PubMed search
was conducted to identify clinical and pathological mechanisms linking obesity to
male infertility. RESULTS: Among the myriad of publications reviewed in this
paper, impaired spermatogenesis and sexual dysfunction have been shown to drive
other variables towards poor fertility potentials. The paper presented a new,
detailed flow chart showing more factors and further interactions among
conditions leading to infertility. CONCLUSIONS: The prime hormonal defect in
obese men is hypotestosteronaemia, which results in impaired spermatogenesis
leading to poor fecundability. Studies have shown that most mechanisms accounting
for reduced fertility potentials in overweight men are reversible.
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