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2013 ; 82
(ä): 25-54
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Mechanisms for initiating cellular DNA replication
#MMPMID23746253
Costa A
; Hood IV
; Berger JM
Annu Rev Biochem
2013[]; 82
(ä): 25-54
PMID23746253
show ga
The initiation of DNA replication represents a committing step to cell
proliferation. Appropriate replication onset depends on multiprotein complexes
that help properly distinguish origin regions, generate nascent replication
bubbles, and promote replisome formation. This review describes initiation
systems employed by bacteria, archaea, and eukaryotes, with a focus on comparing
and contrasting molecular mechanisms among organisms. Although commonalities can
be found in the functional domains and strategies used to carry out and regulate
initiation, many key participants have markedly different activities and appear
to have evolved convergently. Despite significant advances in the field, major
questions still persist in understanding how initiation programs are executed at
the molecular level.