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2015 ; 2
(ä): 10
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Mechanisms determining the fate of hematopoietic stem cells
#MMPMID27358878
Lin S
; Zhao R
; Xiao Y
; Li P
Stem Cell Investig
2015[]; 2
(ä): 10
PMID27358878
show ga
Successful in vitro expansion of hematopoietic stem cells (HSCs) will facilitate
the application of HSC transplantation for the treatment of various diseases,
including hematological malignancies. To achieve this expansion, the molecular
mechanisms that control the fate of HSCs must be deciphered. Leukemia-initiating
cells (LICs) or leukemia stem cells (LSCs) may originate from normal HSCs, which
suggest that the dysregulation of the mechanisms that regulate the cell fate of
HSCs may underlie leukemogenesis. Here we review the recent progress in the
application of HSCs, the regulatory mechanisms of the fate of HSCs, and the
origins of leukemia.