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2015 ; 9
(ä): 458
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Mechanisms and Functional Significance of Stroke-Induced Neurogenesis
#MMPMID26696816
Marlier Q
; Verteneuil S
; Vandenbosch R
; Malgrange B
Front Neurosci
2015[]; 9
(ä): 458
PMID26696816
show ga
Stroke affects one in every six people worldwide, and is the leading cause of
adult disability. After stroke, some limited spontaneous recovery occurs, the
mechanisms of which remain largely unknown. Multiple, parallel approaches are
being investigated to develop neuroprotective, reparative and regenerative
strategies for the treatment of stroke. For years, clinical studies have tried to
use exogenous cell therapy as a means of brain repair, with varying success.
Since the rediscovery of adult neurogenesis and the identification of adult
neural stem cells in the late nineties, one promising field of investigation is
focused upon triggering and stimulating this self-repair system to replace the
neurons lost following brain injury. For instance, it is has been demonstrated
that the adult brain has the capacity to produce large numbers of new neurons in
response to stroke. The purpose of this review is to provide an updated overview
of stroke-induced adult neurogenesis, from a cellular and molecular perspective,
to its impact on brain repair and functional recovery.