Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1021/acsnano.6b05706 http://scihub22266oqcxt.onion/10.1021/acsnano.6b05706 C5348102!5348102 !27943675     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27943675 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       ACS+Nano 2017 ; 11 (1 ): 314-324 Nephropedia Template TP {{tp|p=27943675 |t=2017. Mechanism of Shiga Toxin Clustering on Membranes |pdf=|usr=}}{{27943675 }} gab.com Text Mechanism of Shiga Toxin Clustering on Membranes JO: ACS Nano http://www.kidney.de/pget.php?&tw=1&pmid=27943675 #FOAvip The bacterial Shiga toxin interacts with its cellular receptor, the glycosphingolipid globotriaosylceramide (Gb3 or CD77), as a first step to entering target cells. Previous studies have shown that toxin molecules cluster on the plasma membrane, despite the apparent lack of direct interactions between them. The precise mechanism by which this clustering occurs remains poorly defined. Here, we used vesicle and cell systems and computer simulations to show that line tension due to curvature, height, or compositional mismatch, and lipid or solvent depletion cannot drive the clustering of Shiga toxin molecules. By contrast, in coarse-grained computer simulations, a correlation was found between clustering and toxin nanoparticle-driven suppression of membrane fluctuations, and experimentally we observed that clustering required the toxin molecules to be tightly bound to the membrane surface. The most likely interpretation of these findings is that a membrane fluctuation-induced force generates an effective attraction between toxin molecules. Such force would be of similar strength to the electrostatic force at separations around 1 nm, remain strong at distances up to the size of toxin molecules (several nanometers), and persist even beyond. This force is predicted to operate between manufactured nanoparticles providing they are sufficiently rigid and tightly bound to the plasma membrane, thereby suggesting a route for the targeting of nanoparticles to cells for biomedical applications. Twit Text FOAVip Mechanism of Shiga Toxin Clustering on Membranes ????ACS Nano http://www.kidney.de/pget.php?&tw=1&pmid=27943675 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27943675 #FOAvip English Wikipedia <ref>{{Cite pmid|27943675 }}</ref> Mechanism of Shiga Toxin Clustering on Membranes #MMPMID27943675 Pezeshkian W ; Gao H ; Arumugam S ; Becken U ; Bassereau P ; Florent JC ; Ipsen JH ; Johannes L ; Shillcock JC ACS Nano 2017[Jan]; 11 (1 ): 314-324 PMID27943675 show ga The bacterial Shiga toxin interacts with its cellular receptor, the glycosphingolipid globotriaosylceramide (Gb3 or CD77), as a first step to entering target cells. Previous studies have shown that toxin molecules cluster on the plasma membrane, despite the apparent lack of direct interactions between them. The precise mechanism by which this clustering occurs remains poorly defined. Here, we used vesicle and cell systems and computer simulations to show that line tension due to curvature, height, or compositional mismatch, and lipid or solvent depletion cannot drive the clustering of Shiga toxin molecules. By contrast, in coarse-grained computer simulations, a correlation was found between clustering and toxin nanoparticle-driven suppression of membrane fluctuations, and experimentally we observed that clustering required the toxin molecules to be tightly bound to the membrane surface. The most likely interpretation of these findings is that a membrane fluctuation-induced force generates an effective attraction between toxin molecules. Such force would be of similar strength to the electrostatic force at separations around 1 nm, remain strong at distances up to the size of toxin molecules (several nanometers), and persist even beyond. This force is predicted to operate between manufactured nanoparticles providing they are sufficiently rigid and tightly bound to the plasma membrane, thereby suggesting a route for the targeting of nanoparticles to cells for biomedical applications. |Cell Membrane/*chemistry [MESH] |Humans [MESH] |Nanoparticles/*chemistry [MESH] |Shiga Toxin/*chemistry [MESH] |Static Electricity [MESH]Mechanism of Shiga Toxin Clustering on Membranes (epmc).pdf DeepDyve Pubget Overpricing