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2011 ; 2
(10
): 792-9
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Mechanism and methods to induce pluripotency
#MMPMID22058034
Wang P
; Na J
Protein Cell
2011[Oct]; 2
(10
): 792-9
PMID22058034
show ga
Pluripotent stem cells are able to self-renew indefinitely and differentiate into
all types of cells in the body. They can thus be an inexhaustible source for
future cell transplantation therapy to treat degenerative diseases which
currently have no cure. However, non-autologous cells will cause immune
rejection. Induced pluripotent stem cell (iPSC) technology can convert somatic
cells to the pluripotent state, and therefore offers a solution to this problem.
Since the first generation of iPSCs, there has been an explosion of relevant
research, from which we have learned much about the genetic networks and
epigenetic landscape of pluripotency, as well as how to manipulate genes,
epigenetics, and microRNAs to obtain iPSCs. In this review, we focus on the
mechanism of cellular reprogramming and current methods to induce pluripotency.
We also highlight new problems emerging from iPSCs. Better understanding of the
fundamental mechanisms underlying pluripotenty and refining the methodology of
iPSC generation will have a significant impact on future development of
regenerative medicine.
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