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2011 ; 1
(4
): 2009-27
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Mechanics of the lung in the 20th century
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Mitzner W
Compr Physiol
2011[Oct]; 1
(4
): 2009-27
PMID23733695
show ga
Major advances in respiratory mechanics occurred primarily in the latter half of
the 20th century, and this is when much of our current understanding was secured.
The earliest and ancient investigations involving respiratory physiology and
mechanics were frequently done in conjunction with other scientific activities
and often lacked the ability to make quantitative measurements. This situation
changed rapidly in the 20th century, and this relatively recent history of lung
mechanics has been greatly influenced by critical technological advances and
applications, which have made quantitative experimental testing of ideas
possible. From the spirometer of Hutchinson, to the pneumotachograph of Fleisch,
to the measurement of esophageal pressure, to the use of the Wilhelmy balance by
Clements, and to the unassuming strain gauges for measuring pressure and rapid
paper and electronic chart recorders, these enabling devices have generated
numerous quantitative experimental studies with greatly increased physiologic
understanding and validation of mechanistic theories of lung function in health
and disease.
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