Mechanics of epithelial tissues during gap closure
#MMPMID27131272
Begnaud S
; Chen T
; Delacour D
; Mège RM
; Ladoux B
Curr Opin Cell Biol
2016[Oct]; 42
(?): 52-62
PMID27131272
show ga
The closure of gaps is crucial to maintaining epithelium integrity during
developmental and repair processes such as dorsal closure and wound healing.
Depending on biochemical as well as physical properties of the microenvironment,
gap closure occurs through assembly of multicellular actin-based contractile
cables and/or protrusive activity of cells lining the gap. This review discusses
the relative contributions of 'purse-string' and cell crawling mechanisms
regulated by cell-substrate and cell-cell interactions, cellular mechanics and
physical constraints from the environment.