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2015 ; 87
(6
): 1162-1179
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Mechanically Activated Ion Channels
#MMPMID26402601
Ranade SS
; Syeda R
; Patapoutian A
Neuron
2015[Sep]; 87
(6
): 1162-1179
PMID26402601
show ga
Mechanotransduction, the conversion of physical forces into biochemical signals,
is essential for various physiological processes such as the conscious sensations
of touch and hearing, and the unconscious sensation of blood flow. Mechanically
activated (MA) ion channels have been proposed as sensors of physical force, but
the identity of these channels and an understanding of how mechanical force is
transduced has remained elusive. A number of recent studies on previously known
ion channels along with the identification of novel MA ion channels have greatly
transformed our understanding of touch and hearing in both vertebrates and
invertebrates. Here, we present an updated review of eukaryotic ion channel
families that have been implicated in mechanotransduction processes and evaluate
the qualifications of the candidate genes according to specified criteria. We
then discuss the proposed gating models for MA ion channels and highlight recent
structural studies of mechanosensitive potassium channels.