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2015 ; 32
(5
): 561-73
Nephropedia Template TP
Kim JH
; Ren Y
; Ng WP
; Li S
; Son S
; Kee YS
; Zhang S
; Zhang G
; Fletcher DA
; Robinson DN
; Chen EH
Dev Cell
2015[Mar]; 32
(5
): 561-73
PMID25684354
show ga
Membrane fusion is an energy-consuming process that requires tight juxtaposition
of two lipid bilayers. Little is known about how cells overcome energy barriers
to bring their membranes together for fusion. Previously, we have shown that
cell-cell fusion is an asymmetric process in which an "attacking" cell drills
finger-like protrusions into the "receiving" cell to promote cell fusion. Here,
we show that the receiving cell mounts a Myosin II (MyoII)-mediated
mechanosensory response to its invasive fusion partner. MyoII acts as a
mechanosensor, which directs its force-induced recruitment to the fusion site,
and the mechanosensory response of MyoII is amplified by chemical signaling
initiated by cell adhesion molecules. The accumulated MyoII, in turn, increases
cortical tension and promotes fusion pore formation. We propose that the
protrusive and resisting forces from fusion partners put the fusogenic synapse
under high mechanical tension, which helps to overcome energy barriers for
membrane apposition and drives cell membrane fusion.
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