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10.1016/j.mvr.2014.07.013 http://scihub22266oqcxt.onion/10.1016/j.mvr.2014.07.013 C4267889!4267889 !25107458     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25107458 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Microvasc+Res 2014 ; 96 (ä): 46-54 Nephropedia Template TP {{tp|p=25107458 |t=2014. Mechanical forces and lymphatic transport |pdf=|usr=}}{{25107458 }} gab.com Text Mechanical forces and lymphatic transport JO: Microvasc Res http://www.kidney.de/pget.php?&tw=1&pmid=25107458 #FOAvip This review examines the current understanding of how the lymphatic vessel network can optimize lymph flow in response to various mechanical forces. Lymphatics are organized as a vascular tree, with blind-ended initial lymphatics, precollectors, prenodal collecting lymphatics, lymph nodes, postnodal collecting lymphatics and the larger trunks (thoracic duct and right lymph duct) that connect to the subclavian veins. The formation of lymph from interstitial fluid depends heavily on oscillating pressure gradients to drive fluid into initial lymphatics. Collecting lymphatics are segmented vessels with unidirectional valves, with each segment, called a lymphangion, possessing an intrinsic pumping mechanism. The lymphangions propel lymph forward against a hydrostatic pressure gradient. Fluid is returned to the central circulation both at lymph nodes and via the larger lymphatic trunks. Several recent developments are discussed, including evidence for the active role of endothelial cells in lymph formation; recent developments on how inflow pressure, outflow pressure, and shear stress affect the pump function of the lymphangion; lymphatic valve gating mechanisms; collecting lymphatic permeability; and current interpretations of the molecular mechanisms within lymphatic endothelial cells and smooth muscle. An improved understanding of the physiological mechanisms by which lymphatic vessels sense mechanical stimuli, integrate the information, and generate the appropriate response is key for determining the pathogenesis of lymphatic insufficiency and developing treatments for lymphedema. Twit Text FOAVip Mechanical forces and lymphatic transport ????Microvasc Res http://www.kidney.de/pget.php?&tw=1&pmid=25107458 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25107458 #FOAvip English Wikipedia <ref>{{Cite pmid|25107458 }}</ref> Mechanical forces and lymphatic transport #MMPMID25107458 Breslin JW Microvasc Res 2014[Nov]; 96 (ä): 46-54 PMID25107458 show ga This review examines the current understanding of how the lymphatic vessel network can optimize lymph flow in response to various mechanical forces. Lymphatics are organized as a vascular tree, with blind-ended initial lymphatics, precollectors, prenodal collecting lymphatics, lymph nodes, postnodal collecting lymphatics and the larger trunks (thoracic duct and right lymph duct) that connect to the subclavian veins. The formation of lymph from interstitial fluid depends heavily on oscillating pressure gradients to drive fluid into initial lymphatics. Collecting lymphatics are segmented vessels with unidirectional valves, with each segment, called a lymphangion, possessing an intrinsic pumping mechanism. The lymphangions propel lymph forward against a hydrostatic pressure gradient. Fluid is returned to the central circulation both at lymph nodes and via the larger lymphatic trunks. Several recent developments are discussed, including evidence for the active role of endothelial cells in lymph formation; recent developments on how inflow pressure, outflow pressure, and shear stress affect the pump function of the lymphangion; lymphatic valve gating mechanisms; collecting lymphatic permeability; and current interpretations of the molecular mechanisms within lymphatic endothelial cells and smooth muscle. An improved understanding of the physiological mechanisms by which lymphatic vessels sense mechanical stimuli, integrate the information, and generate the appropriate response is key for determining the pathogenesis of lymphatic insufficiency and developing treatments for lymphedema. |Animals [MESH] |Biological Transport [MESH] |Endothelial Cells [MESH] |Extracellular Fluid [MESH] |Humans [MESH] |Lymph Nodes [MESH] |Lymphatic System/*physiology [MESH] |Lymphatic Vessels/*physiology [MESH] |Lymphedema [MESH] |Mice [MESH] |Permeability [MESH] |Pressure [MESH] |Shear Strength [MESH]Mechanical forces and lymphatic transport (epmc).pdf DeepDyve Pubget Overpricing