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2014 ; 126
(ä): 317-52
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Mechanical force sensing in tissues
#MMPMID25081624
Chanet S
; Martin AC
Prog Mol Biol Transl Sci
2014[]; 126
(ä): 317-52
PMID25081624
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Tissue size, shape, and organization reflect individual cell behaviors such as
proliferation, shape change, and movement. Evidence suggests that mechanical
signals operate in tandem with biochemical cues to properly coordinate cell
behavior and pattern tissues. The objective of this chapter is to present recent
evidence demonstrating that forces transmitted between cells act as signals that
coordinate cell behavior across tissues. We first briefly summarize molecular and
cellular mechanisms by which forces are sensed by cells with an emphasis on
forces generated and transmitted by cytoskeletal networks. We then discuss
evidence for these mechanisms operating in multicellular contexts to coordinate
complex cell and tissue behaviors that occur during embryonic development:
specifically growth and morphogenesis.