Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26261279
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Cold+Spring+Harb+Perspect+Biol
2015 ; 8
(3
): a019232
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Mechanical Forces and Growth in Animal Tissues
#MMPMID26261279
LeGoff L
; Lecuit T
Cold Spring Harb Perspect Biol
2015[Aug]; 8
(3
): a019232
PMID26261279
show ga
Mechanical forces shape biological tissues. They are the effectors of the
developmental programs that orchestrate morphogenesis. A lot of effort has been
devoted to understanding morphogenetic processes in mechanical terms. In this
review, we focus on the interplay between tissue mechanics and growth. We first
describe how tissue mechanics affects growth, by influencing the orientation of
cell divisions and the signaling pathways that control the rate of volume
increase and proliferation. We then address how the mechanical state of a tissue
is affected by the patterns of growth. The forward and reverse interactions
between growth and mechanics must be investigated in an integrative way if we
want to understand how tissues grow and shape themselves. To illustrate this
point, we describe examples in which growth homeostasis is achieved by feedback
mechanisms that use mechanical forces.