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2016 ; 55
(ä): 80-8
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Measuring time during early embryonic development
#MMPMID26994526
Ferree PL
; Deneke VE
; Di Talia S
Semin Cell Dev Biol
2016[Jul]; 55
(ä): 80-8
PMID26994526
show ga
In most metazoans, embryonic development is orchestrated by a precise series of
cellular behaviors. Understanding how such events are regulated to achieve a
stereotypical temporal progression is a fundamental problem in developmental
biology. In this review, we argue that studying the regulation of the cell cycle
in early embryonic development will reveal novel principles of how embryos
accurately measure time. We will discuss the strategies that have emerged from
studying early development of Drosophila embryos. By comparing the development of
flies to that of other metazoans, we will highlight both conserved and
alternative mechanisms to generate precision during embryonic development.