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10.1016/j.molcel.2015.10.009 http://scihub22266oqcxt.onion/10.1016/j.molcel.2015.10.009 C4656081!4656081 !26549682     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26549682 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Cell 2015 ; 60 (4 ): 685-96 Nephropedia Template TP {{tp|p=26549682 |t=2015. Measuring In Vivo Mitophagy |pdf=|usr=}}{{26549682 }} gab.com Text Measuring In Vivo Mitophagy JO: Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=26549682 #FOAvip Alterations in mitophagy have been increasingly linked to aging and age-related diseases. There are, however, no convenient methods to analyze mitophagy in vivo. Here, we describe a transgenic mouse model in which we expressed a mitochondrial-targeted form of the fluorescent reporter Keima (mt-Keima). Keima is a coral-derived protein that exhibits both pH-dependent excitation and resistance to lysosomal proteases. Comparison of a wide range of primary cells and tissues generated from the mt-Keima mouse revealed significant variations in basal mitophagy. In addition, we have employed the mt-Keima mice to analyze how mitophagy is altered by conditions including diet, oxygen availability, Huntingtin transgene expression, the absence of macroautophagy (ATG5 or ATG7 expression), an increase in mitochondrial mutational load, the presence of metastatic tumors, and normal aging. The ability to assess mitophagy under a host of varying environmental and genetic perturbations suggests that the mt-Keima mouse should be a valuable resource. Twit Text FOAVip Measuring In Vivo Mitophagy ????Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=26549682 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26549682 #FOAvip English Wikipedia <ref>{{Cite pmid|26549682 }}</ref> Measuring In Vivo Mitophagy #MMPMID26549682 Sun N ; Yun J ; Liu J ; Malide D ; Liu C ; Rovira II ; Holmström KM ; Fergusson MM ; Yoo YH ; Combs CA ; Finkel T Mol Cell 2015[Nov]; 60 (4 ): 685-96 PMID26549682 show ga Alterations in mitophagy have been increasingly linked to aging and age-related diseases. There are, however, no convenient methods to analyze mitophagy in vivo. Here, we describe a transgenic mouse model in which we expressed a mitochondrial-targeted form of the fluorescent reporter Keima (mt-Keima). Keima is a coral-derived protein that exhibits both pH-dependent excitation and resistance to lysosomal proteases. Comparison of a wide range of primary cells and tissues generated from the mt-Keima mouse revealed significant variations in basal mitophagy. In addition, we have employed the mt-Keima mice to analyze how mitophagy is altered by conditions including diet, oxygen availability, Huntingtin transgene expression, the absence of macroautophagy (ATG5 or ATG7 expression), an increase in mitochondrial mutational load, the presence of metastatic tumors, and normal aging. The ability to assess mitophagy under a host of varying environmental and genetic perturbations suggests that the mt-Keima mouse should be a valuable resource. |*Mice, Transgenic [MESH] |*Mitophagy [MESH] |Aging/physiology [MESH] |Animals [MESH] |Luminescent Proteins/genetics/*metabolism [MESH] |Mice [MESH] |Organ Specificity [MESH]Measuring In Vivo Mitophagy (epmc).pdf DeepDyve Pubget Overpricing