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2010 ; 10
(6
): 440-52
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Mast cell-orchestrated immunity to pathogens
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Abraham SN
; St John AL
Nat Rev Immunol
2010[Jun]; 10
(6
): 440-52
PMID20498670
show ga
Although mast cells were discovered more than a century ago, their functions
beyond their role in allergic responses remained elusive until recently. However,
there is a growing appreciation that an important physiological function of these
cells is the recognition of pathogens and modulation of appropriate immune
responses. Because of their ability to instantly release several pro-inflammatory
mediators from intracellular stores and their location at the host-environment
interface, mast cells have been shown to be crucial for optimal immune responses
during infection. Mast cells seem to exert these effects by altering the
inflammatory environment after detection of a pathogen and by mobilizing various
immune cells to the site of infection and to draining lymph nodes. Interestingly,
the character and timing of these responses can vary depending on the type of
pathogen stimulus, location of pathogen recognition and sensitization state of
the responding mast cells. Recent studies using mast cell activators as effective
vaccine adjuvants show the potential of harnessing these cells to confer
protective immunity against microbial pathogens.
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