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2017 ; 34
(3
): 351-361
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Mast cell glycosaminoglycans
#MMPMID27900574
Mulloy B
; Lever R
; Page CP
Glycoconj J
2017[Jun]; 34
(3
): 351-361
PMID27900574
show ga
Mast cells contain granules packed with a mixture of proteins that are released
on degranulation. The proteoglycan serglycin carries an array of
glycosaminoglycan (GAG) side chains, sometimes heparin, sometimes chondroitin or
dermatan sulphate. Tight packing of granule proteins is dependent on the presence
of serglycin carrying these GAGs. The GAGs of mast cells were most intensively
studied in the 1970s and 1980s, and though something is known about the fine
structure of chondroitin sulphate and dermatan sulphate in mast cells, little is
understood about the composition of the heparin/heparan sulphate chains. Recent
emphasis on the analysis of mast cell heparin from different species and tissues,
arising from the use of this GAG in medicine, lead to the question of whether
variations within heparin structures between mast cell populations are as
significant as variations in the mix of chondroitins and heparins.
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