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10.1038/nmeth.4155 http://scihub22266oqcxt.onion/10.1038/nmeth.4155 C5330809!5330809 !28135255     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28135255 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Methods 2017 ; 14 (3 ): 263-266 Nephropedia Template TP {{tp|p=28135255 |t=2017. Massively multiplex single-cell Hi-C |pdf=|usr=}}{{28135255 }} gab.com Text Massively multiplex single-cell Hi-C JO: Nat Methods http://www.kidney.de/pget.php?&tw=1&pmid=28135255 #FOAvip We present single-cell combinatorial indexed Hi-C (sciHi-C), a method that applies combinatorial cellular indexing to chromosome conformation capture. In this proof of concept, we generate and sequence six sciHi-C libraries comprising a total of 10,696 single cells. We use sciHi-C data to separate cells by karyotypic and cell-cycle state differences and identify cell-to-cell heterogeneity in mammalian chromosomal conformation. Our results demonstrate that combinatorial indexing is a generalizable strategy for single-cell genomics. Twit Text FOAVip Massively multiplex single-cell Hi-C ????Nat Methods http://www.kidney.de/pget.php?&tw=1&pmid=28135255 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28135255 #FOAvip English Wikipedia <ref>{{Cite pmid|28135255 }}</ref> Massively multiplex single-cell Hi-C #MMPMID28135255 Ramani V ; Deng X ; Qiu R ; Gunderson KL ; Steemers FJ ; Disteche CM ; Noble WS ; Duan Z ; Shendure J Nat Methods 2017[Mar]; 14 (3 ): 263-266 PMID28135255 show ga We present single-cell combinatorial indexed Hi-C (sciHi-C), a method that applies combinatorial cellular indexing to chromosome conformation capture. In this proof of concept, we generate and sequence six sciHi-C libraries comprising a total of 10,696 single cells. We use sciHi-C data to separate cells by karyotypic and cell-cycle state differences and identify cell-to-cell heterogeneity in mammalian chromosomal conformation. Our results demonstrate that combinatorial indexing is a generalizable strategy for single-cell genomics. |*Molecular Conformation [MESH] |Cell Cycle/genetics [MESH] |Cell Line, Tumor [MESH] |Chromosomes/*genetics [MESH] |DNA/analysis/*genetics [MESH] |Gene Library [MESH] |Genome, Human/*genetics [MESH] |Genomics/*methods [MESH] |HeLa Cells [MESH] |High-Throughput Nucleotide Sequencing/methods [MESH] |Humans [MESH] |Sequence Analysis, DNA/methods [MESH]Massively multiplex single-cell Hi-C (epmc).pdf DeepDyve Pubget Overpricing