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2014 ; 115
(1
): 24-31
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Mapping the human toxome by systems toxicology
#MMPMID24443875
Bouhifd M
; Hogberg HT
; Kleensang A
; Maertens A
; Zhao L
; Hartung T
Basic Clin Pharmacol Toxicol
2014[Jul]; 115
(1
): 24-31
PMID24443875
show ga
Toxicity testing typically involves studying adverse health outcomes in animals
subjected to high doses of toxicants with subsequent extrapolation to expected
human responses at lower doses. The low-throughput of current toxicity testing
approaches (which are largely the same for industrial chemicals, pesticides and
drugs) has led to a backlog of more than 80,000 chemicals to which human beings
are potentially exposed whose potential toxicity remains largely unknown.
Employing new testing strategies that employ the use of predictive,
high-throughput cell-based assays (of human origin) to evaluate perturbations in
key pathways, referred as pathways of toxicity, and to conduct targeted testing
against those pathways, we can begin to greatly accelerate our ability to test
the vast 'storehouses' of chemical compounds using a rational, risk-based
approach to chemical prioritization and provide test results that are more
predictive of human toxicity than current methods. The NIH Transformative
Research Grant project Mapping the Human Toxome by Systems Toxicology aims at
developing the tools for pathway mapping, annotation and validation as well as
the respective knowledge base to share this information.
free
free
free
