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10.1016/j.coi.2013.03.003 http://scihub22266oqcxt.onion/10.1016/j.coi.2013.03.003 C5946314!5946314 !23582509     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23582509 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Curr+Opin+Immunol 2013 ; 25 (3 ): 381-8 Nephropedia Template TP {{tp|p=23582509 |t=2013. Manipulating the PD-1 pathway to improve immunity |pdf=|usr=}}{{23582509 }} gab.com Text Manipulating the PD-1 pathway to improve immunity JO: Curr Opin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=23582509 #FOAvip PD-1 is an inhibitory receptor induced in T cells by antigen stimulation and sustained PD-1 expression plays a key role in T cell dysfunction. Blocking PD-1 signaling rescues exhausted T cells and is an effective treatment for chronic infections and cancer. Nonetheless, combining PD-1 pathway blockade to therapeutic vaccination should further improve T cell rescue. PD-1 is induced shortly after T cell priming, but little is known about the role of PD-1 in the initiation of immune responses. In addition, the PD-1 pathway may also modulate humoral responses, since both B cells and Tfh cells express PD-1. Therefore, even though much progress has been achieved by manipulation of the PD-1 pathway to rescue exhausted T cells, this powerful immunotherapy could still be further exploited. Twit Text FOAVip Manipulating the PD-1 pathway to improve immunity ????Curr Opin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=23582509 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23582509 #FOAvip English Wikipedia <ref>{{Cite pmid|23582509 }}</ref> Manipulating the PD-1 pathway to improve immunity #MMPMID23582509 Kamphorst AO ; Ahmed R Curr Opin Immunol 2013[Jun]; 25 (3 ): 381-8 PMID23582509 show ga PD-1 is an inhibitory receptor induced in T cells by antigen stimulation and sustained PD-1 expression plays a key role in T cell dysfunction. Blocking PD-1 signaling rescues exhausted T cells and is an effective treatment for chronic infections and cancer. Nonetheless, combining PD-1 pathway blockade to therapeutic vaccination should further improve T cell rescue. PD-1 is induced shortly after T cell priming, but little is known about the role of PD-1 in the initiation of immune responses. In addition, the PD-1 pathway may also modulate humoral responses, since both B cells and Tfh cells express PD-1. Therefore, even though much progress has been achieved by manipulation of the PD-1 pathway to rescue exhausted T cells, this powerful immunotherapy could still be further exploited. |*Signal Transduction [MESH] |Animals [MESH] |Gene Expression Regulation [MESH] |Humans [MESH] |Ligands [MESH] |Programmed Cell Death 1 Receptor/genetics/*immunology [MESH] |T-Lymphocytes/immunology [MESH]Manipulating the PD-1 pathway to improve immunity (epmc).pdf DeepDyve Pubget Overpricing