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2015 ; 8
(ä): 309-18
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Managing comorbidities in idiopathic pulmonary fibrosis
#MMPMID26451121
Fulton BG
; Ryerson CJ
Int J Gen Med
2015[]; 8
(ä): 309-18
PMID26451121
show ga
Major risk factors for idiopathic pulmonary fibrosis (IPF) include older age and
a history of smoking, which predispose to several pulmonary and extra-pulmonary
diseases. IPF can be associated with additional comorbidities through other
mechanisms as either a cause or a consequence of these diseases. We review the
literature regarding the management of common pulmonary and extra-pulmonary
comorbidities, including chronic obstructive pulmonary disease, lung cancer,
pulmonary hypertension, venous thromboembolism, sleep-disordered breathing,
gastroesophageal reflux disease, coronary artery disease, depression and anxiety,
and deconditioning. Recent studies have provided some guidance on the management
of these diseases in IPF; however, most treatment recommendations are
extrapolated from studies of non-IPF patients. Additional studies are required to
more accurately determine the clinical features of these comorbidities in
patients with IPF and to evaluate conventional treatments and management
strategies that are beneficial in non-IPF populations.