Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26041964
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26041964
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Clin+Exp+Hepatol
2015 ; 5
(Suppl 1
): S82-7
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Management of overt hepatic encephalopathy
#MMPMID26041964
Sharma P
; Sharma BC
J Clin Exp Hepatol
2015[Mar]; 5
(Suppl 1
): S82-7
PMID26041964
show ga
Hepatic encephalopathy (HE) is an important complication of cirrhosis with
significant morbidity and mortality. Management of HE primarily involves
avoidance of precipitating factors and administration of various ammonia-lowering
therapies such as non-absorbable disaccharides, antimicrobial agents like
rifaximin and l-ornithine l-aspartate. The non-absorbable disaccharides which
include lactulose and lactitol are considered the first-line therapy for the
treatment of HE and in primary and secondary prophylaxis of HE. Lactitol is
comparable to lactulose in the treatment of HE with fewer side effects. Rifaximin
is effective in treatment of HE and recent systemic reviews found it comparable
to disaccharides and is effective in secondary prophylaxis of HE. Many agents
like l-ornithine l-aspartate, probiotics, zinc, sodium benzoate have been tried
either alone or in combination with lactulose for the treatment of HE.
Combination therapy of disaccharides either with rifaximin, l-ornithine
l-aspartate, probiotics for the treatment of HE needs further validation in large
studies.