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10.2147/VHRM.S75399 http://scihub22266oqcxt.onion/10.2147/VHRM.S75399 C4841406!4841406 !27143909     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27143909 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27143909 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Vasc+Health+Risk+Manag 2016 ; 12 (ä): 153-61 Nephropedia Template TP {{tp|p=27143909 |t=2016. Management of intracerebral hemorrhage--use of statins |pdf=|usr=}}{{27143909 }} gab.com Text Management of intracerebral hemorrhage--use of statins JO: Vasc Health Risk Manag http://www.kidney.de/pget.php?&tw=1&pmid=27143909 #FOAvip Intracerebral hemorrhage (ICH) is a neurologic injury resulting in significant morbidity and mortality. Statins play a significant role in primary and secondary prevention of cardiovascular and cerebrovascular ischemic events. Despite clear benefits of statins in ischemic stroke, post hoc analyses of some studies suggest there may be a link between statin therapy and development of ICH. Direct pharmacologic effects of decreased serum levels of total cholesterol and low-density lipoproteins in conjunction with pleiotropic effects are thought to be linked to this possible increase in ICH risk. In the face of the potential of statins to increase the risk of ICH, recent evidence suggests that statins may also have beneficial effects on patient outcomes when continued or initiated following an ICH. This discordance in findings and the overall lack of well-designed prospective clinical trials increase the complexity of clinical decision making when utilizing statin therapy in patients with, or at risk for, ICH. This review evaluates the pharmacologic effects of statin therapy and describes how these effects translate to both risks and benefits in ICH. The current literature regarding the effects of statin therapy on clinical outcomes in ICH is evaluated to help guide clinicians with decisions regarding initiation, continuation, or discontinuation of statin therapy in patients with ICH. Twit Text FOAVip Management of intracerebral hemorrhage--use of statins ????Vasc Health Risk Manag http://www.kidney.de/pget.php?&tw=1&pmid=27143909 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27143909 #FOAvip English Wikipedia <ref>{{Cite pmid|27143909 }}</ref> Management of intracerebral hemorrhage--use of statins #MMPMID27143909 Van Matre ET ; Sherman DS ; Kiser TH Vasc Health Risk Manag 2016[]; 12 (ä): 153-61 PMID27143909 show ga Intracerebral hemorrhage (ICH) is a neurologic injury resulting in significant morbidity and mortality. Statins play a significant role in primary and secondary prevention of cardiovascular and cerebrovascular ischemic events. Despite clear benefits of statins in ischemic stroke, post hoc analyses of some studies suggest there may be a link between statin therapy and development of ICH. Direct pharmacologic effects of decreased serum levels of total cholesterol and low-density lipoproteins in conjunction with pleiotropic effects are thought to be linked to this possible increase in ICH risk. In the face of the potential of statins to increase the risk of ICH, recent evidence suggests that statins may also have beneficial effects on patient outcomes when continued or initiated following an ICH. This discordance in findings and the overall lack of well-designed prospective clinical trials increase the complexity of clinical decision making when utilizing statin therapy in patients with, or at risk for, ICH. This review evaluates the pharmacologic effects of statin therapy and describes how these effects translate to both risks and benefits in ICH. The current literature regarding the effects of statin therapy on clinical outcomes in ICH is evaluated to help guide clinicians with decisions regarding initiation, continuation, or discontinuation of statin therapy in patients with ICH. |Animals [MESH] |Biomarkers/blood [MESH] |Cerebral Hemorrhage/chemically induced/diagnosis/*drug therapy/mortality [MESH] |Humans [MESH] |Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects/*therapeutic use [MESH] |Lipids/blood [MESH] |Patient Selection [MESH] |Risk Assessment [MESH] |Risk Factors [MESH]Management of intracerebral hemorrhage--use of statins (epmc).pdf DeepDyve Pubget Overpricing