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2014 ; 99
(6
): 965-72
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Management of chronic lymphocytic leukemia
#MMPMID24881042
Ghia P
; Hallek M
Haematologica
2014[Jun]; 99
(6
): 965-72
PMID24881042
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In the last decade, the management of chronic lymphocytic leukemia has undergone
profound changes that have been driven by an improved understanding of the
biology of the disease and the approval of several new drugs. Moreover, many
novel drugs are currently under evaluation for rapid approval or have been
approved by regulatory agencies, further broadening the available therapeutic
armamentarium for patients with chronic lymphocytic leukemia. The use of novel
biological and genetic parameters combined with a careful clinical evaluation
allows us to dissect some of the heterogeneity of the disease and to distinguish
patients with a very mild onset and course, who often will not need any
treatment, from those with an intermediate prognosis and a third group with a
very aggressive course (high-risk leukemia). On this background, it becomes
increasingly challenging to select the right treatment strategy. In this paper,
we describe our own approach to the management of different patients with chronic
lymphocytic leukemia.
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