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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 United+European+Gastroenterol+J
2015 ; 3
(3
): 277-83
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Management of acute variceal bleeding using hemostatic powder
#MMPMID26137303
Ibrahim M
; El-Mikkawy A
; Abdalla H
; Mostafa I
; Devière J
United European Gastroenterol J
2015[Jun]; 3
(3
): 277-83
PMID26137303
show ga
BACKGROUND AND OBJECTIVES: This study aimed to test the safety and efficacy of
Hemospray® for emergency control of acute variceal bleeding (AVB) due to portal
hypertension in cirrhotic patients. PATIENTS AND METHODS: This single-arm,
prospective trial, conducted at two hospitals in Belgium and Egypt, included
patients admitted to the emergency room with hematemesis and/or melena and known
or suspected liver cirrhosis. All patients received urgent hemodynamic
stabilization, octreotide (50 mcg bolus then 25?mcg/hour for 24 hours) and
intravenous ceftriaxone (1?g/hour). Endoscopy to confirm AVB and Hemospray®
application (if indicated) was performed within six hours of admission. Patients
were kept under observation for 24 hours and underwent second endoscopy and
definitive therapy (band ligation and/or cyanoacrylate injection in cases of
gastric varices) the next day. RESULTS: Thirty-eight patients were admitted for
suspected AVB, and 30 of these had confirmed AVB (70% male; mean age 59.5 years
(range, 32.0-73 years)). Child-Pugh class C liver disease was present in 53.4%.
Esophageal varices were observed in 83.4% of patients, gastric varices in 10%,
and duodenal varices in 6.6%. Spurting bleeding at the time of endoscopy was
observed in 43.4%. One patient developed hematemesis six hours after Hemospray®
application and underwent emergency endoscopic band ligation. No major adverse
events or mortalities were observed during 15-day follow-up. CONCLUSION:
Hemospray® application was safe and effective at short-term follow-up for
emergency treatment of AVB in cirrhotic patients.