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2017 ; 216
(1
): 73-82
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Mammalian synthetic biology for studying the cell
#MMPMID27932576
Mathur M
; Xiang JS
; Smolke CD
J Cell Biol
2017[Jan]; 216
(1
): 73-82
PMID27932576
show ga
Synthetic biology is advancing the design of genetic devices that enable the
study of cellular and molecular biology in mammalian cells. These genetic devices
use diverse regulatory mechanisms to both examine cellular processes and achieve
precise and dynamic control of cellular phenotype. Synthetic biology tools
provide novel functionality to complement the examination of natural cell
systems, including engineered molecules with specific activities and model
systems that mimic complex regulatory processes. Continued development of
quantitative standards and computational tools will expand capacities to probe
cellular mechanisms with genetic devices to achieve a more comprehensive
understanding of the cell. In this study, we review synthetic biology tools that
are being applied to effectively investigate diverse cellular processes,
regulatory networks, and multicellular interactions. We also discuss current
challenges and future developments in the field that may transform the types of
investigation possible in cell biology.
free
free
free
