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10.1016/j.gde.2017.02.004 http://scihub22266oqcxt.onion/10.1016/j.gde.2017.02.004 C5777332!5777332 !28391084     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28391084 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28391084 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Curr+Opin+Genet+Dev 2017 ; 42 (ä): 56-67 Nephropedia Template TP {{tp|p=28391084 |t=2017. Mammalian SWI/SNF complexes in cancer: emerging therapeutic opportunities |pdf=|usr=}}{{28391084 }} gab.com Text Mammalian SWI/SNF complexes in cancer: emerging therapeutic opportunities JO: Curr Opin Genet Dev http://www.kidney.de/pget.php?&tw=1&pmid=28391084 #FOAvip Mammalian SWI/SNF (BAF) chromatin remodeling complexes orchestrate a diverse set of chromatin alterations which impact transcriptional output. Recent whole-exome sequencing efforts have revealed that the genes encoding subunits of mSWI/SNF complexes are mutated in over 20% of cancers, spanning a wide range of tissue types. The majority of mutations result in loss of subunit protein expression, implicating mSWI/SNF subunits as tumor suppressors. mSWI/SNF-deficient cancers remain a therapeutic challenge, owing to a lack of potent and selective agents which target complexes or unique pathway dependencies generated by mSWI/SNF subunit perturbations. Here, we review the current landscape of mechanistic insights and emerging therapeutic opportunities for human malignancies driven by mSWI/SNF complex perturbation. Twit Text FOAVip Mammalian SWI/SNF complexes in cancer: emerging therapeutic opportunities ????Curr Opin Genet Dev http://www.kidney.de/pget.php?&tw=1&pmid=28391084 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28391084 #FOAvip English Wikipedia <ref>{{Cite pmid|28391084 }}</ref> Mammalian SWI/SNF complexes in cancer: emerging therapeutic opportunities #MMPMID28391084 St Pierre R ; Kadoch C Curr Opin Genet Dev 2017[Feb]; 42 (ä): 56-67 PMID28391084 show ga Mammalian SWI/SNF (BAF) chromatin remodeling complexes orchestrate a diverse set of chromatin alterations which impact transcriptional output. Recent whole-exome sequencing efforts have revealed that the genes encoding subunits of mSWI/SNF complexes are mutated in over 20% of cancers, spanning a wide range of tissue types. The majority of mutations result in loss of subunit protein expression, implicating mSWI/SNF subunits as tumor suppressors. mSWI/SNF-deficient cancers remain a therapeutic challenge, owing to a lack of potent and selective agents which target complexes or unique pathway dependencies generated by mSWI/SNF subunit perturbations. Here, we review the current landscape of mechanistic insights and emerging therapeutic opportunities for human malignancies driven by mSWI/SNF complex perturbation. |Animals [MESH] |Chromosomal Proteins, Non-Histone/antagonists & inhibitors/*genetics [MESH] |Humans [MESH] |Mammals [MESH] |Mutation [MESH] |Neoplasms/*genetics/therapy [MESH]Mammalian SWI/SNF complexes in cancer: emerging therapeutic opportunit(epmc).pdf DeepDyve Pubget Overpricing