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10.3390/ijms18061117 http://scihub22266oqcxt.onion/10.3390/ijms18061117 C5485941!5485941 !28538697     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28538697 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Mol+Sci 2017 ; 18 (6 ): ä Nephropedia Template TP {{tp|p=28538697 |t=2017. Mammalian Metallothionein-3: New Functional and Structural Insights |pdf=|usr=}}{{28538697 }} gab.com Text Mammalian Metallothionein-3: New Functional and Structural Insights JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28538697 #FOAvip Metallothionein-3 (MT-3), a member of the mammalian metallothionein (MT) family, is mainly expressed in the central nervous system (CNS). MT-3 possesses a unique neuronal growth inhibitory activity, and the levels of this intra- and extracellularly occurring metalloprotein are markedly diminished in the brain of patients affected by a number of metal-linked neurodegenerative disorders, including Alzheimer's disease (AD). In these pathologies, the redox cycling of copper, accompanied by the production of reactive oxygen species (ROS), plays a key role in the neuronal toxicity. Although MT-3 shares the metal-thiolate clusters with the well-characterized MT-1 and MT-2, it shows distinct biological, structural and chemical properties. Owing to its anti-oxidant properties and modulator function not only for Zn, but also for Cu in the extra- and intracellular space, MT-3, but not MT-1/MT-2, protects neuronal cells from the toxicity of various Cu(II)-bound amyloids. In recent years, the roles of zinc dynamics and MT-3 function in neurodegeneration are slowly emerging. This short review focuses on the recent developments regarding the chemistry and biology of MT-3. Twit Text FOAVip Mammalian Metallothionein-3: New Functional and Structural Insights ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28538697 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28538697 #FOAvip English Wikipedia <ref>{{Cite pmid|28538697 }}</ref> Mammalian Metallothionein-3: New Functional and Structural Insights #MMPMID28538697 Va?ák M ; Meloni G Int J Mol Sci 2017[May]; 18 (6 ): ä PMID28538697 show ga Metallothionein-3 (MT-3), a member of the mammalian metallothionein (MT) family, is mainly expressed in the central nervous system (CNS). MT-3 possesses a unique neuronal growth inhibitory activity, and the levels of this intra- and extracellularly occurring metalloprotein are markedly diminished in the brain of patients affected by a number of metal-linked neurodegenerative disorders, including Alzheimer's disease (AD). In these pathologies, the redox cycling of copper, accompanied by the production of reactive oxygen species (ROS), plays a key role in the neuronal toxicity. Although MT-3 shares the metal-thiolate clusters with the well-characterized MT-1 and MT-2, it shows distinct biological, structural and chemical properties. Owing to its anti-oxidant properties and modulator function not only for Zn, but also for Cu in the extra- and intracellular space, MT-3, but not MT-1/MT-2, protects neuronal cells from the toxicity of various Cu(II)-bound amyloids. In recent years, the roles of zinc dynamics and MT-3 function in neurodegeneration are slowly emerging. This short review focuses on the recent developments regarding the chemistry and biology of MT-3. |Animals [MESH] |Copper/metabolism [MESH] |Humans [MESH] |Metallothionein 3 [MESH] |Metallothionein/chemistry/metabolism [MESH] |Models, Molecular [MESH] |Nerve Tissue Proteins/chemistry/*metabolism [MESH] |Neurodegenerative Diseases/*metabolism/pathology [MESH] |Neurons/metabolism/pathology [MESH] |Protein Conformation [MESH] |Reactive Oxygen Species/metabolism [MESH]Mammalian Metallothionein-3: New Functional and Structural Insights (epmc).pdf DeepDyve Pubget Overpricing