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2014 ; 91
(6
): 1094-100
Nephropedia Template TP
Am J Trop Med Hyg
2014[Dec]; 91
(6
): 1094-100
PMID25294615
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Splenic infarction is a rare complication of malaria. We report two recent cases
of splenic infarction after Plasmodium vivax infection. No systematic review of
malaria-induced splenic infarction was available, therefore we conducted a
systematic review of the English, French, and Spanish literature in PubMed and
KoreaMed for reports of malaria-associated splenic infarction from 1960 to 2012.
Of the 40 cases collected on splenic infarction by Plasmodium species, 23
involved P. vivax, 11 Plasmodium falciparum, one Plasmodium ovale, and five a
mixed infection of P. vivax and P. falciparum. Of the 40 cases, 2 (5.0%) involved
splenectomy and 5 (12.5%) were accompanied by splenic rupture. The median time
from symptom onset to diagnosis was 8.5 days (range, 3-90 days). Improved
findings after treatment were observed in 8 (88.9%) of 9 patients with splenic
infarction on follow-up by computed tomography or ultrasonography. All patients
survived after treatment with the exception of one patient with cerebral malaria.
Clinicians should consider the possibility of splenic infarction when
malaria-infected patients have left upper quadrant pain.
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