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2015 ; 125
(17
): 2621-9
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Making sense of hematopoietic stem cell niches
#MMPMID25762174
Boulais PE
; Frenette PS
Blood
2015[Apr]; 125
(17
): 2621-9
PMID25762174
show ga
The hematopoietic stem cell (HSC) niche commonly refers to the pairing of
hematopoietic and mesenchymal cell populations that regulate HSC self-renewal,
differentiation, and proliferation. Anatomic localization of the niche is a
dynamic unit from the developmental stage that allows proliferating HSCs to
expand before they reach the bone marrow where they adopt a quiescent phenotype
that protects their integrity and functions. Recent studies have sought to
clarify the complexity behind the HSC niche by assessing the contributions of
specific cell populations to HSC maintenance. In particular, perivascular
microenvironments in the bone marrow confer distinct vascular niches that
regulate HSC quiescence and the supply of lineage-committed progenitors. Here, we
review recent data on the cellular constituents and molecular mechanisms involved
in the communication between HSCs and putative niches.